{"id":5032,"date":"2020-10-18T11:00:15","date_gmt":"2020-10-18T05:30:15","guid":{"rendered":"https:\/\/atuljha.com\/blog\/?p=5032"},"modified":"2020-10-18T11:00:15","modified_gmt":"2020-10-18T05:30:15","slug":"aging-3","status":"publish","type":"post","link":"https:\/\/atuljha.com\/blog\/2020\/10\/18\/aging-3\/","title":{"rendered":"Aging"},"content":{"rendered":"\n<p>Started reading lifespan by David A. Sinclair. The book talks about aging and argues it to be treated like any other disease. Excerpt from the book.&nbsp;<\/p>\n\n\n\n<p>These are the multiple hallmarks of aging.&nbsp;<\/p>\n\n\n\n<ul><li>Genomic instability caused by DNA damage.<\/li><li>Attrition of the protective chromosomal endcaps<\/li><li>Alterations to the epigenome that controls which genes are turned on and off.<\/li><li>Loss of healthy protein maintenance.<\/li><li>Deregulated nutrient sensing caused by metabolic changes.<\/li><li>Mitochondrial dysfunction<\/li><li>Exhaustion of stem cells<\/li><li>Altered intercellular communication and the production of inflammatory molecules<\/li><li>Accumulation of senescent zombielike cells that inflate a healthy cell&nbsp;<\/li><\/ul>\n\n\n\n<p>&nbsp;Excerpt from the book&nbsp;<em>lifespan by David A. Sinclair.&nbsp;<\/em><\/p>\n\n\n\n<p>Fun fact, I don&#8217;t know most of the terminology explained above. I am hopeful after finishing the book I will be able to, otherwise, I have some friends in this field who will help me in understanding it.&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Started reading lifespan by David A. Sinclair. The book talks about aging and argues it to be treated like any other disease. Excerpt from the book.&nbsp; These are the multiple hallmarks of aging.&nbsp; Genomic instability caused by DNA damage. Attrition of the protective chromosomal endcaps Alterations to the epigenome that controls which genes are turned &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/atuljha.com\/blog\/2020\/10\/18\/aging-3\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Aging&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[249,100],"tags":[549],"_links":{"self":[{"href":"https:\/\/atuljha.com\/blog\/wp-json\/wp\/v2\/posts\/5032"}],"collection":[{"href":"https:\/\/atuljha.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/atuljha.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/atuljha.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/atuljha.com\/blog\/wp-json\/wp\/v2\/comments?post=5032"}],"version-history":[{"count":1,"href":"https:\/\/atuljha.com\/blog\/wp-json\/wp\/v2\/posts\/5032\/revisions"}],"predecessor-version":[{"id":5033,"href":"https:\/\/atuljha.com\/blog\/wp-json\/wp\/v2\/posts\/5032\/revisions\/5033"}],"wp:attachment":[{"href":"https:\/\/atuljha.com\/blog\/wp-json\/wp\/v2\/media?parent=5032"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/atuljha.com\/blog\/wp-json\/wp\/v2\/categories?post=5032"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/atuljha.com\/blog\/wp-json\/wp\/v2\/tags?post=5032"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}