A lot many innovations happened because of personal itch. Be it a bicycle mechanic building the first airplane or an entrepreneur building a rocket, an electric car, or a solar company. A patent commissioner coming up with innovation in the area of physics or a philosopher coming up with mathematical formulas.
Also, it is not necessary that you would know everything. If you have the itch, you will find people, hire, mentor, and partner.
Our time on this planet is limited, and it gives us enough opportunity to work on our itch. There is no time to complain or crib about what you don’t have and can’t do because of limitations.
Frank Kafka, Van Gogh or Ramanujan has that itch. They gave us the best of literature, art, or mathematics leaving early. They had that itch.